Status:
UNKNOWN
The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Lead Sponsor:
Uppsala University
Conditions:
Mechanical Ventilation Complication
Neurological Complication
Eligibility:
All Genders
18+ years
Brief Summary
Mechanical ventilation (MV) is a life-saving supportive therapy and one of the most common interventions implemented in intensive care. To date, only the inspiratory phase of breathing has been exten...
Eligibility Criteria
Inclusion
- Neurosurgical patients on mechanical ventilation and with ongoing intracerebral pressure monitoring will be included in the study
- Age \>18 years;
- MV expected for more than 72 hours;
- Not pregnant;
- Informed consent from patient or next of kin.
Exclusion
- Previously demonstrated paralysis of the diaphragm or know pathology of the phrenic nerve or neuromuscular disorder;
- Chest tube;
- Patients with clinical conditions that contraindicate the insertion of esophageal/gastric catheters (e.g., esophagus rupture, esophageal bleeding);
- Pacemaker and/or implantable cardioverter defibrillator, these last being a contraindication for EIT;
- Hemicraniectomy. In case of late hemicraniectomy (after patient inclusion), the patient will drop-out from the study.
- Relative contraindication: in case of skull base fracture the patient can be included only if oesophageal/gastric and NAVA catheters can be inserted orally.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05363098
Start Date
May 1 2022
End Date
May 1 2023
Last Update
May 5 2022
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