Status:
COMPLETED
Atopic Dermatitis: Sub-Saharan Africa vs. Central Europe
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Regional Dermatology Training Centre (RDTC), Moshi, Tanzania
University Hospital Joseph Raseta Befelatanana in Antananarivo, Madagascar
Conditions:
Atopic Dermatitis
Eligibility:
All Genders
18+ years
Brief Summary
Many people are affected by atopic dermatitis (AD) worldwide. However, clinical studies on AD in Sub-Saharan Africa are rare and there is a lack of knowledge about possible differences in pathogenesis...
Detailed Description
Objectives of the project: Compare the following aspects in patients suffering from atopic dermatitis (AD) and healthy control (HC) participants in Central Europe (CE) vs. Sub-Saharan Africa (SsA): *...
Eligibility Criteria
Inclusion
- AD patients:
- Age: ≥18 years
- Written informed consent given after information about the research project
- Suffering from active atopic dermatitis
- No active skin disease other than atopic dermatitis
- No known active inflammatory disease other than atopic dermatitis/atopic diseases
- HC participants:
- Age: ≥18 years
- Written informed consent given after information about the research project
- No active skin disease
- No known atopic disease (atopic dermatitis, asthma, allergy, allergic rhinoconjuncitivitis)
- No known active inflammatory disease
Exclusion
- Known or suspected systemic immunosuppression because of disease
- Systemic immunomodulatory/-suppressive treatment
- Glucocorticoids or immunosuppressants (last 4 weeks) or
- JAK inhibitors (last week) or
- Omalizumab (last 4 weeks) or
- Other biologicals e.g. dupilumab (last 2 months)
- Clinical signs of active bacterial, fungal or viral infection
- Systemic antibiotic, antimycotic or antiviral treatment 4 weeks prior to start
- Phototherapy 4 weeks prior to start
- Active neoplasia
- Undergoing surgery in the last 2 months
- Infarction (e.g. stroke), embolism, or thrombosis in the last 2 months
- Inability to follow the study procedures e.g. due to language problems, dementia etc. of the participant
Key Trial Info
Start Date :
March 30 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 12 2025
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT05363904
Start Date
March 30 2022
End Date
March 12 2025
Last Update
July 9 2025
Active Locations (3)
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1
University Hospital Joseph Raseta Befelatanana
Antananarivo, Madagascar
2
University Hospital Zurich
Zurich, Switzerland
3
Regional Dermatology Training Centre (RDTC)
Moshi, Tanzania