Status:
COMPLETED
Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Major Abdominal Surgery Patients
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Cardiac Output
Decreased Cardiac Output
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to investigate the hemodynamic effects of two strategies of alveolar recruitment maneuver in patients undergoing major abdominal surgery in the operating room
Detailed Description
In practice, after induction of general anesthesia and intubation, patients will be conditioned with the recommended monitoring (arterial catheter, central venous catheter, and transpulmonary thermodi...
Eligibility Criteria
Inclusion
- patient over 18 years old
- patient under general anesthesia
- patient intubated under controlled invasive mechanical ventilation
- patient with invasive hemodynamic monitoring (transpulmonary thermodilution)
- patient sedated (BIS between 40 and 60) and/or curarized with TOF monitoring to avoid inspiratory effort
- patient optimized on the hemodynamic level, in particular with regard to blood volume, following the hemodynamic monitoring data and the recommendations of the French Society of Anesthesia and Resuscitation (RFE SFAR 2013 - Perioperative vascular filling strategy)
- patient covered by a Social Security plan
- patient consent to participate in the study
Exclusion
- contraindication to the use of cardiac output measurement
- cardiac arrhythmia
- pace-maker/implantable defibrillator
- severe valvulopathy
- contraindication to the use of the tomographic electroimpedancemetry technique
- thoracic lesions, thoracic dressing
- left ventricular ejection fraction (LVEF) \< 45% and/or right ventricular failure.
- history of pulmonary lobectomy and/or pneumonectomy and/or known emphysema
- patient with restrictive or obstructive lung disease
- body mass index (BMI) \< 16.5 or \> 30 kg.m-2
- pregnancy
- intracranial hypertension or suspected intracranial hypertension
- patient under limitation of care
- patient under legal protection (guardianship, curatorship, safeguard of justice)
Key Trial Info
Start Date :
March 9 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05365113
Start Date
March 9 2022
End Date
May 31 2022
Last Update
June 18 2023
Active Locations (1)
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1
CHU
Clermont-Ferrand, France, 63000