Status:
WITHDRAWN
HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Recurrent Pregnancy Loss Without Current Pregnancy
Eligibility:
FEMALE
18-42 years
Phase:
PHASE2
Brief Summary
Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points towards endometriosis and progesterone resistance as an underlying cause of uRPL. Previous non-RCT studies h...
Detailed Description
Fifty (50) patients with unexplained recurrent pregnancy loss, defined as 2 or more losses. Workup will exclude structural, genetic, hormonal, and anti-phospholipid syndrome-related causes of RPL. Wom...
Eligibility Criteria
Inclusion
- 2 first trimester losses
- unexplained recurrent pregnancy loss
Exclusion
- Antiphospholipid syndrome
- uterine septum
- Asherman's syndrome
- Paternal or maternal genetic abnormalities (i.e. balanced translocation)
- Endocrine causes of RPL (thyroid, diabetes, hyperprolactinemia)
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT05365464
Start Date
May 1 2022
End Date
December 1 2025
Last Update
May 9 2022
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