Status:
RECRUITING
Neoadjuvant Chemotherapy Followed by Chemoradiation Versus Chemoradiation for Stage IIIC Cervical Cancer Patients: A Randomized Phase III Trial
Lead Sponsor:
Sun Yat-sen University
Conditions:
Cervical Cancer
Neoadjuvant Chemotherapy
Eligibility:
FEMALE
18-70 years
Phase:
PHASE3
Brief Summary
Evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with albumin-bound paclitaxel and carboplatin followed by chemoradiation therapy (CRT) for stage IIIC cervical cancer patients with c...
Detailed Description
in this phase III tiral , stage IIIC cervical cancer patients with carcinoma \>4 cm in greatest dimension and/or lymph node \>2cm in short axis will be randomly assigned to two circles of NAC with alb...
Eligibility Criteria
Inclusion
- pathologically comfirmed : squamous cell, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix；
- FIGO (2018 International Federation of Gynecology and Obstetrics) stage IIIC with carcinoma \>4 cm in greatest dimension and/or lymph node \>2 cm in short axis at initial diagnosis.
- age 18 to 70 years；
- Eastern Cooperative Oncology Group performance status 0 to 2；
- adequate organ function.
Exclusion
- 1\. not at initial diagnosis; 2. with other kind of tumor.
- \-
Key Trial Info
Start Date :
March 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT05367206
Start Date
March 14 2022
End Date
March 31 2027
Last Update
May 10 2022
Active Locations (1)
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1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdone, China, 510000