Status:
COMPLETED
Brain Changes in Pediatric OSA
Lead Sponsor:
University of California, Los Angeles
Conditions:
Pediatric Obstructive Sleep Apnea
Eligibility:
All Genders
7-12 years
Phase:
NA
Brief Summary
Obstructive sleep apnea (OSA) is highly prevalent in children and is often caused by overgrowth of the child's adenoids and/or tonsils. Consequently, adenotonsillectomy (removal of the tonsils and ade...
Detailed Description
Pediatric obstructive sleep apnea (OSA) is a common and progressive syndrome accompanied by severe cognition, mood, and daytime behavioral issues, as well as poor school performance, presumably stemmi...
Eligibility Criteria
Inclusion
- OSA
- Pediatric OSA subjects will be in the age range 7-12 years (upper and lower age limit will be chosen to avoid developmental-related brain changes and potential requirement of anesthesia for brain MRI)
- Have a diagnosis of at least moderate OSA (AHI\>5 events/hour) via overnight polysomnography at a sleep laboratory
- Without obesity (≥95th percentile BMI for age and sex) to avoid perioperative issues
- No treatment for the breathing condition
- Undergoing for adenotonsillectomy.
- Control subjects
- Healthy children
- Age-range from 7-12 years (within ±3 months)
- Sex- and BMI-matched (±2 kg/m2) to pediatric OSA
- No medications for brain disorders
- Without any diagnosed neurological condition
Exclusion
- Previous history of diagnosed psychiatric diseases (depression and other brain disorders that may introduce brain injury)
- Cystic fibrosis, concussion, and presence of space-occupying brain lesions
- Metallic or electronic implants and other MRI-specific exclusion criteria
Key Trial Info
Start Date :
May 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2024
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT05368077
Start Date
May 14 2022
End Date
July 31 2024
Last Update
November 29 2024
Active Locations (1)
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1
UCLA
Los Angeles, California, United States, 90095