Status:
RECRUITING
Long-term COVID and Rehabilitation
Lead Sponsor:
VA Office of Research and Development
Conditions:
Long-COVID
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by c...
Detailed Description
COVID-19 induces profound vascular endothelial dysfunction, the long-term impact of which is unknown. Moreover, recovery from COVID-19 is delayed in a substantial number of COVID-19 patients (\~ 30-4...
Eligibility Criteria
Inclusion
- 50 years of age or greater
- Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
- Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
- Ability to sign informed consent
Exclusion
- BMI \>45 kg/m2
- Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia
- Orthopedic limitations that would prohibit exercise
- \[Current smokers and individuals that stopped smoking in the last 10 years\]
- Already taking Mito-Q or unwilling to cease dietary supplements for participation
- Any other condition or event considered exclusionary by the PIs or a physician
Key Trial Info
Start Date :
November 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05373043
Start Date
November 1 2022
End Date
October 31 2028
Last Update
September 18 2025
Active Locations (1)
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1
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States, 84148-0001