Status:
NOT_YET_RECRUITING
Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Monitoring Circulating Tumor DNA
Lead Sponsor:
University Hospital, Rouen
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of the REMNANT study is to confirm the clinical value of detecting a new biomarker, ctDNA (circulating tumor DNA), in the follow-up of patients with operated liver cancer. In order to meet th...
Detailed Description
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and develops in 80% of cases in the context of underlying cirrhosis1. Surgical resection, percutaneous destruction and liver tran...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- HCC diagnosed on consensus radiological criteria in cirrhotic patients (EASL-EORTC 2012): helical CT or MRI with triple arterial, portal and late acquisition. The diagnosis is based on the presence of hypervascularization at the early arterial time (wash-in) with wash-out (hypodensity or hypointensity compared to non-tumor liver parenchyma) at the portal phase or late phase compared to non-tumor parenchyma.
- HCC diagnosed histologically in the absence of a diagnosis on imaging (see IC n°2 above)
- Patient operated on for liver resection or radiofrequency destruction
- Treatment decision validated by the digestive oncology PCR
- Patient having read and understood the information letter and signed the non-opposition form
- Patient follow-up at the Charles Nicolle University Hospital in Rouen
Exclusion
- Other active cancer or hematological malignancy
- Contra-indication to surgery
- Patient not affiliated to the social security system
- Pregnant woman or parturient or breastfeeding
- Person under court protection, sub guardianship or curatorship
Key Trial Info
Start Date :
September 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05375370
Start Date
September 1 2022
End Date
September 1 2026
Last Update
May 20 2022
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