Status:
COMPLETED
The Effect on Metabolism, Food Intake and Preferences of a Knockout Gene Variant Involved in Carbohydrate Metabolism
Lead Sponsor:
Steno Diabetes Center Copenhagen
Collaborating Sponsors:
The Novo Nordisk Foundation Center for Basic Metabolic Research
Department of Food Science, University of Copenhagen
Conditions:
Diabetes Mellitus, Type 2
Metabolic Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Around 10% has type 2 diabetes in Greenland, despite being a practically unknown disease only six decades ago. The drastic increase is of great concern, especially considering the transition that have...
Detailed Description
In this human study, effects of the SI knockout variant on metabolism, dietary habits and food preferences will be quantified. The study will be unique by being the first assessing the effect of a com...
Eligibility Criteria
Inclusion
- Homozygous carriers of the c.273\_274delAG variant in the SI-gene (cases)
- Homozygous non-carriers of the c.273\_274delAG variant in the SI-gene (controls)
Exclusion
- Diagnosis of diabetes or pharmacological treatment of diabetes.
- Gastrointestinal diseases such as inflammatory bowel disease, gastrointestinal cancer, and ulcer. Persons with mild gastrointestinal problems are not excluded, e.g. persons with lactose-intolerance who normally do not have any gastrointestinal problems.
- Homozygous carriers of the TBC1D4 risk variant p.Arg684Ter.
- Lack of compliance with the procedures in the study protocol, judged by Investigator.
- For the homozygous carriers of the c.273\_274delAG variant: rise in blood glucose in an oral sucrose tolerance test.
Key Trial Info
Start Date :
January 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 7 2022
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT05375656
Start Date
January 8 2022
End Date
May 7 2022
Last Update
May 31 2022
Active Locations (2)
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1
Maniitsoq Healthcare Center
Maniitsoq, Greenland
2
Pikialaarfik, Greenland Institute of Natural Resources
Nuussuaq, Greenland, 3905