Status:
COMPLETED
Central Blood Pressure and Variability Evaluation
Lead Sponsor:
Imperial College Healthcare NHS Trust
Collaborating Sponsors:
London North West Healthcare NHS Trust
Conditions:
AAA
Abdominal Aortic Aneurysm
Eligibility:
All Genders
55+ years
Brief Summary
Background: A sub-study of the AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK) trial indicated a statistically significant association between central blood pressu...
Detailed Description
The AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK) trial was designed to investigate the hypothesis that an ACE-inhibitor (perindopril) would reduce growth rate o...
Eligibility Criteria
Inclusion
- Willing and able to give written informed consent
- infrarenal aneurysms of ≥3cm in size (to include AAA ≥5.5cm in those not proceeding to surgery)
Exclusion
- Patient's with a known genetic aetiology of their AAA
- age\<55
- known bilateral proximal upper extremity obstructive lesions
- persistent cardiac arrhythmia
- those unable to give informed consent
- those too frail to travel for four monthly surveillance
- any clinically significant medical condition which, in the opinion of the investigator, may interfere with the study results and/or reduce life expectancy to \< 2 years
- participation in another trial of an investigational product or device within the previous 30 days
- unable or unwilling to comply with the requirements of the study, in the opinion of the investigator
Key Trial Info
Start Date :
June 7 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2024
Estimated Enrollment :
137 Patients enrolled
Trial Details
Trial ID
NCT05376514
Start Date
June 7 2022
End Date
June 30 2024
Last Update
January 31 2025
Active Locations (2)
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1
Northwick Park Hospital, London North West Healthcare NHS Trust
London, United Kingdom, HA1 3UJ
2
St Mary's Hospital, Imperial College Healthcare NHS Trust
London, United Kingdom, W2 1NY