Status:
ACTIVE_NOT_RECRUITING
Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
Congressionally Directed Medical Research Programs
Conditions:
Gulf War Illness
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
This project's objective is to identify effective treatments for Gulf War Illness (GWI). The project tests three potential treatments: curcumin, stinging nettle, and resveratrol. The project uses a de...
Detailed Description
The project is funded by the Congressionally Directed Medical Research Programs (CDMRP) of the U.S. Department of Defense. The study uses a prospective, pseudo-randomized, placebo-controlled, blinded...
Eligibility Criteria
Inclusion
- In accordance with the Institute of Medicine (IOM) 2014 guidance, participants must meet both the Kansas and CDC (Centers for Disease Control and Prevention) Case Definitions of GWI. Participants must have been deployed to the Persian Gulf Region during the 1990-1991 Gulf War, meet symptom domain criteria, and not have exclusionary medical conditions. The case definitions will be used for inclusionary screening purposes.
- Meets Kansas GWI Case Definition
- Meets CDC GWI Case Definition
- Able to commit to a 10-month study
Exclusion
- Currently involved in an experimental treatment study
- Abnormal liver function values
- Abnormal kidney function values
- Currently pregnant
- Blood clotting disorder (contraindicated with all three botanicals)
- Reported diagnosis of diabetes with an A1C greater than 9
- The use of contraindicated medications (see below):
- Anticoagulant medications (such as warfarin, heparin, etc.)
- Lithium
- Tacrolimus (Prograf)
- Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)
Key Trial Info
Start Date :
May 31 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2026
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT05377242
Start Date
May 31 2023
End Date
June 30 2026
Last Update
November 26 2025
Active Locations (1)
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1
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233