Status:
UNKNOWN
Backward Masking Tasks to Decipher Impaired Input-Output Connections in MS @7T
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Difference in Regional Brain Activity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system. People with MS frequently suffer from cognitive and visual impairment. Moreover, patients...
Detailed Description
To identify abnormalities in mesoscale input and output connectivity at structural and functional levels that differ between patients with and without cognitive impairment. To address this objective, ...
Eligibility Criteria
Inclusion
- Adult patients (\>= 18 years of age) with MS defined according to the McDonald criteria 2017 (Thompson et al., 2018)
- For the group of patients without cognitive impairment: SDMT or PASAT \>=0 (based previous clinical assessments)
- For the group of patients with cognitive impairment: SD SDMT or PASAT \<= -1.5 (based based on previous clinical assessments) (Parmenter et al., 2007)
- Person without uncontrolled systemic disease such as cancer, autoimmune disease, liver failure, severe or untreated hypertension, conduction conduction disorder or severe rhythm disorder
- No one with chronic psychiatric illness, severe dementia syndrome demented syndrome.
- No contraindication to MRI examination (claustrophobia, metallic foreign bodies, pacemakers),
- A person with social security coverage,
- Person having read, understood and signed an informed consent after information
Exclusion
- Pregnant women
- Other inflammatory demyelinating diseases of the CNS
- Usual contraindications for an MRI examination: claustrophobia, metallic foreign bodies pacemakers, severe renal insufficiency.
Key Trial Info
Start Date :
October 13 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05377671
Start Date
October 13 2022
End Date
January 1 2024
Last Update
October 19 2022
Active Locations (1)
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1
Assistance Publique Hopitaux Marseille
Marseille, Bouches Du Rhône, France, 13354