Status:
COMPLETED
Identification of Diabetic Nephropathy Biomarkers Through Transcriptomics
Lead Sponsor:
Hospital Juarez de Mexico
Conditions:
Type 2 Diabetes
Type 2 Diabetes With Renal Manifestations
Eligibility:
All Genders
18-65 years
Brief Summary
According to the different epidemiological studies in Mexico the prevalence of diabetic nephropathy is 9.1%-40% in diabetic patients, however the complication is subdiagnosed when we see the numbers o...
Detailed Description
Type 2 diabetes (T2D) is defined as a group of metabolic diseases characterized by chronic hyperglycemia, resulting from defects in insulin secretion, insulin action or both. According to the National...
Eligibility Criteria
Inclusion
- Patients with ≥ 20 years of T2D evolution with normoalbuminuria
- Patients without a personal or family history of kidney disease in 1st degree relatives Age ≥ 18 years
- T2D diagnosed at least 5 years before initiating renal replacement therapy Background or diabetic retinopathy by self-report to ensure that albuminuria was the consequence of diabetic nephropathy rather than a non-diabetic glomerulopathy albuminuria ≥ 300 mg/24 h in at least two out of three sterile urine samples no hematuria or signs (including cellular casts), history or predisposition to other kidney or urinary tract disease.
Exclusion
- Diabetic patients without diabetic nephropathy
- Patients with type 1 diabetes, gesta- tional diabetes, uncontrollable hypertension, active cancer, heart failure, liver or kidney disease, cotreatment with corticosteroids or estrogens, conditions that can cause hyperglycemia, addiction to alcohol or illegal drugs, and dementia or severe psychiatric disor- ders were not included in this study
Key Trial Info
Start Date :
September 3 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05378282
Start Date
September 3 2021
End Date
February 28 2023
Last Update
February 28 2023
Active Locations (1)
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1
Hospital Juárez de México
Mexico City, Mexico, 07760