Status:
COMPLETED
Cleaner Air for Better Cardiac Biomarkers
Lead Sponsor:
NYU Langone Health
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
This pilot project is a randomized, double-blind, sham-controlled trial investigating whether in-home air pollution reductions using portable air cleaners (PACs) can decrease circulating concentration...
Detailed Description
In Aim 1, the researchers will evaluate associations with PAC use with a priori specified biomarker of inflammation, tumor necrosis factor alpha (TNFα). The researchers will determine if 4 weeks of ho...
Eligibility Criteria
Inclusion
- Participant is ≥18 years old
- Participant and members of household are reported to be non-smokers (defined as no household members are currently known to smoke cigarettes or use other tobacco products including e-cigarettes)
- Participant is to understand/speak English or Spanish
- Participant can understand study procedures and give informed consent
- Participant has stable hypertension: no medication changes in prior 30 days, systolic BP \<160 mm Hg and either ≥ 130 mm Hg without antihypertensive medications, or diagnosis of hypertension in medical records
- Able to measure home blood pressure twice daily
- Able to participate in video conference for home equipment setup
- Able to visit clinic for blood draws before and after the study period
- Do not intend to sleep anywhere outside of primary bedroom for more than 48 consecutive hours or a total of 7 days during the study period.
- Ability to lift, or access to assistance with lifting, 20 lb to set up PAC in bedroom.
Exclusion
- Participants who are unable to provide a minimum of at least one blood pressure measurement per day
- Participants with average home blood pressure monitor readings of a systolic blood pressure (SBP) \>160 mmHg over any 10-day period during the study. This will be considered evidence of uncontrolled hypertension and will require study termination.
- Participants with known coronary artery disease
- Participants with known systemic inflammatory conditions (such as rheumatoid arthritis, inflammatory bowel disease, cancer)
- Participants currently taking any anti-inflammatory medications or medications that target inflammatory cytokines
- Pregnancy
Key Trial Info
Start Date :
August 11 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 24 2023
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05379400
Start Date
August 11 2022
End Date
August 24 2023
Last Update
December 6 2024
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016