Status:
COMPLETED
Salivary Biomarkers for Concussion Recovery
Lead Sponsor:
State University of New York at Buffalo
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Concussion, Brain
Eligibility:
All Genders
13-18 years
Phase:
NA
Brief Summary
The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise. The investigato...
Detailed Description
* This is a four-arm randomized control trial that investigates the changes in expression of BDNF/ miRNA after prescribed exercise intervention in concussed adolescents. Potential participants will be...
Eligibility Criteria
Inclusion
- • Adolescent and adult athletes (age 13-18) diagnosed with SRC within 10 days of injury.
Exclusion
- Evidence of focal neurological deficit;
- Inability to exercise because of orthopedic or cervical spine injury;
- Increased cardiac risk according to American College of Sports Medicine criteria;
- History of moderate or severe TBI, defined as brain injury with a Glasgow Coma Scale score of 12 or less;
- Current medication treatment for ADHD, learning disorders, depression, anxiety, or other medications that can affect HR;
- Symptom severity score of less than 5 on the initial visit Post Concussion Symptom Scale questionnaire. (7) currently pregnant (8) have any contraindications to exercise (Physical Activity Readiness-Questionnaire)
Key Trial Info
Start Date :
March 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 13 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05379920
Start Date
March 22 2022
End Date
January 13 2023
Last Update
January 3 2024
Active Locations (1)
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1
UB MD Orthopeadics & Sports Medicine
Buffalo, New York, United States, 14214