Status:
UNKNOWN
Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients.
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Conditions:
Anorexia
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
This study was 8 weeks randomized, double-blind trail to assess the effect of mirtazapine versus megestrol acetate in treatment of anorexia-cachexia in advanced cancer patients in 80 patients. Partici...
Detailed Description
Cancer-related cachexia and anorexia (CRCA) comprises one of the most common syndrome of advanced cancers characterize by anorexia, tissue wasting and loss of body weight accompanied by a decrease in ...
Eligibility Criteria
Inclusion
- Patients aged ≥ 18 years, with a histologically diagnosed advanced-stage tumor at any site.
- Assumptive or documented loss of \>5% of pre-illness or ideal body weight (body mass index) in the previous 3 months.
- Patients could be receiving concomitant chemotherapy, radiotherapy and/or palliative supportive care.
- Patients ECOG Performance Status 0-3.
Exclusion
- Patients with a mechanical obstruction to feeding.
- Patients with high doses of corticosteroids.
- Patients with clinically bulky ascites and generalized edema.
- Patients with inability to take oral medications.
- History of uncontrolled diabetes mellitus and hypertension.
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05380479
Start Date
June 1 2022
End Date
February 1 2023
Last Update
May 18 2022
Active Locations (1)
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1
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh, 1000