Status:
COMPLETED
Quantification of Antisense HIV RNA in Patients
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
HIV-1-infection
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this study is to quantify the expression levels of the HIV-1 unspliced sense transcript and of total HIV-1 antisense transcripts in PBMCs of HIV-1-infected persons, either still untre...
Detailed Description
The research team will quantify the expression level of total HIV-1 antisense transcripts in PBMCs from two groups of HIV-1-infected persons: still untreated and virologically controllled on treatment...
Eligibility Criteria
Inclusion
- HIV-1 infection
- ability to understand the objectives and protocols of the research and to sign the informed consent
- \* group 1 : treatment-naive patients with a detectable HIV-1 viral load
- Have not received any antiretroviral treatment
- At the chronic stage as determined during the clinical examination and confirmed by a western blot complete HIV antigens ("env" bands (gp 120 and 160). + "gag" and "pol" bands) with the presence of p31+
- \*Group 2: patients with chronic HIV-1 infection on antiretroviral therapy efficient
- Have been on antiretroviral therapy for less than a year
- With a plasma HIV RNA \< 50 copies/mL of blood for at least 6 months
Exclusion
- ongoing HIV primary infection
- coinfection with HIV-2 or HTLV-1/2
- ongoing AIDS-defining clinical condition
- ongoing infectious disease of any type
- ongoing immunosuppressive treatment
- incompetent adults, persons under the protection of a conservator, tutor or guardian
- participation in a trial testing a medication in the 3 months preceding blood sampling
- pregnant or lactating woman
Key Trial Info
Start Date :
October 20 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 18 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05381844
Start Date
October 20 2022
End Date
October 18 2024
Last Update
March 12 2025
Active Locations (1)
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1
Jean-Paul VIARD
Paris, France, 75004