Status:
RECRUITING
Effect of FMD on Colorectal Cancer Patients
Lead Sponsor:
Fudan University
Collaborating Sponsors:
Shanghai Cancer Hospital, China
Huashan Hospital
Conditions:
Fasting Mimicking Diet
Colorectal Cancer
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Extensive preclinical evidence suggests that short-term fasting and fasting mimicking diets (FMDs) can protect healthy cells and render cancer cells more vulnerable to chemotherapy and other therapies...
Eligibility Criteria
Inclusion
- Age 18 \~ 80 years old
- Patients undergoing radical colorectal cancer resection for the first time
- Preoperative clinical tumor stage III
- ASA grade I-III grade
- With BMI 19-32 kg/m2
- Adequate liver function, adequate renal function and normal cardiac function
- Willing to participate in the research of the subject and agree to follow up regularly
Exclusion
- Evidence of distant metastasis before surgery
- Before surgery, have received treatment of neoadjuvant chemotherapy
- Type 1 diabetes or intensive insulin therapy
- Allergies for FMD content
- Combined with severe primary diseases such as severe immune system or autoimmune system or long-term using of glucocorticoids or immunosuppressant
- History of opioid abuse, mental illness or cognitive impairment
Key Trial Info
Start Date :
June 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 30 2025
Estimated Enrollment :
602 Patients enrolled
Trial Details
Trial ID
NCT05384444
Start Date
June 8 2022
End Date
October 30 2025
Last Update
January 5 2024
Active Locations (6)
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1
Fudan University Huashan Hospital
Shanghai, Shanghai Municipality, China, 200032
2
Fudan University Shanghai Cancer center
Shanghai, Shanghai Municipality, China, 200032
3
Fudan University,ZhongShan Hospital
Shanghai, Shanghai Municipality, China, 200032
4
Shanghai Changhai Hospital, Naval Medical University,
Shanghai, Shanghai Municipality, China, 200032