Status:
UNKNOWN
Effect of Prebiotics on Hyperuricemia
Lead Sponsor:
Sun Yat-sen University
Conditions:
Subjects With Hyperuricemia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of Hyperuricemia. Animal studies h...
Detailed Description
Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of hyperuricemia. Animal studies h...
Eligibility Criteria
Inclusion
- Local residents aged between 18-65 years old;
- Stable weight (\<5% weight change over last 3 months);
- Fasting uric acid was \> 420μmol/L for male and \> 360μmol/L for female on two different days
- Those who have never taken uric acid lowering drugs or have stopped taking uric acid lowering drugs for at least four weeks;
- Absence of any diet or medication that might interfere with Uric acid metabolism and gut microbiota, especially antibiotics and probiotics at least 4 weeks before recruitment.
Exclusion
- Acute illness or evidence of any acute or chronic inflammatory of infective diseases;
- Participation in regular diet program more than 2 times per week in the latest 3 months prior to recruitment;
- Mental illness rendering them unable to understand the nature, scope, and possible consequences of the study.
- Women of childbearing age who are pregnant, breast-feeding or preparing for pregnancy; Patients who had surgery within the past six months or planned surgery during the trial period
Key Trial Info
Start Date :
May 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05385003
Start Date
May 14 2022
End Date
December 31 2023
Last Update
May 23 2022
Active Locations (2)
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1
Department of Nutrition and Food Hygiene
Guangzhou, Guangdong, China, 510080
2
Sun Yat-Sen University
Guangzhou, Guangdong, China, 510080