Status:
RECRUITING
Identification of Hepatic Fibrosis Using 4D-MRI
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Liver Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To date, no specific treatment options exist for liver diseases, and there is a large global effort to find drugs that will halt liver disease progression in these patients.Liver fibrosis staging is e...
Detailed Description
Chronic liver diseases represent a rising global health threat. A prolonged inflammatory state leads to progressive fibrosis that can result in liver cirrhosis associated with serious complications in...
Eligibility Criteria
Inclusion
- age ≥ 18 years
- (a) Patients with histologically confirmed chronic liver disease, including NAFLD, ALD, viral hepatitis B and C, genetic (e.g. Wilson disease, hemochromatosis) or autoimmune liver disease
- (b) Patients with acute liver inflammation or cardiac blood congestion to the liver (as assessed by laboratory values, imaging findings and clinical history)
- ability to understand and consent to participate in this study
Exclusion
- Medical implant like cardiac pacemaker, pump, hip prosthesis
- Metallic objects in the body (e.g. splinters after an accident)
- Persons who have undergone brain or cardiac surgery
- Claustrophobia
- Body Weight \>140kg or as provided by the MR manufacturer
- Pregnant and lactating women
- (a) Active hepatocellular carcinoma (HCC) (remark: patients with a history of HCC and curative treatment can be included)
- (a) CHILD C cirrhosis
- (a) and (b) Patients with overt ascites (except if they respond to diuretic treatment and the ascites resolves)
- (c) Metabolic syndrome, BMI \>30 kg/m2
- (c) Acute or chronic liver disease
- Patients not willing or able to give a written informed consent
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05385237
Start Date
August 1 2021
End Date
December 31 2026
Last Update
March 18 2025
Active Locations (2)
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1
Kantonsspital Baselland (KSL)
Liestal, Basel-Landschaft, Switzerland, 4410
2
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4052