Status:
ACTIVE_NOT_RECRUITING
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
Lead Sponsor:
University College Cork
Collaborating Sponsors:
University Hospital, Ghent
University Hospital Waterford
Conditions:
Multimorbidity
Polypharmacy
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medicatio...
Detailed Description
Background: Recurrent hospitalization and unplanned emergency department (ED) attendance resulting from potentially inappropriate medication is an increasingly common phenomenon in older people with ...
Eligibility Criteria
Inclusion
- Age ≥ 70years
- 3 or more chronic conditions.
- ≥ 5 daily medications pre-admission, all medications taken for at least 4 weeks continuously.
- Can speak and understand English (in the two Irish medical centres), and Dutch or French in Ghent University Hospital (Ghent is predominantly Dutch-speaking).
- Can give informed consent or give witnessed verbal consent or have a suitable proxy who can give informed assent on the patient's behalf.
- Agrees to follow-up contact post-discharge up to 180 days post-randomization.
- Agrees to primary researcher contacting the GP and community pharmacist post-discharge.
Exclusion
- Terminal illness.
- Severe dementia and clearly unable to understand the purpose of the trial or give consent to participation.
- Severe communication disorder, making informed consent impossible.
- Likely to be discharged from hospital within 48 hours of arrival.
- Intensive Care Unit (ICU) admission.
- Primary psychiatric presenting illness.
- Unavailable for post-discharge follow-up for any reason.
- Non-accidental poisoning.
- Previous participation in medication optimization trials.
- Active participation in another clinical trial
- Infectious illness requiring strict isolation (including COVID-19 infection) blocking access of the primary researcher to the patient for enrolment.
- End-stage renal, liver or lung disease requiring organ replacement therapy.
- Admitted under the care of specialists in Clinical Pharmacology, Palliative Medicine, Clinical Oncology or Haematology.
- Admitted under the care of specialists in Geriatric Medicine in Ghent University Hospital.
- Trial participation refusal.
Key Trial Info
Start Date :
January 17 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
642 Patients enrolled
Trial Details
Trial ID
NCT05387096
Start Date
January 17 2023
End Date
August 31 2024
Last Update
July 10 2024
Active Locations (3)
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1
Ghent University Hospital
Ghent, Belgium, 9000
2
Cork University Hospital
Cork, Ireland
3
University Hospital Waterford
Waterford, Ireland