Status:
COMPLETED
A Real World Study of β2-Adrenergic Blocker Plus PD-1 Inhibitor in Non-Small Cell Lung Cancer
Lead Sponsor:
Affiliated Hospital of Nantong University
Collaborating Sponsors:
The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Conditions:
Lung Cancer
Eligibility:
All Genders
18-100 years
Brief Summary
This study aims to explore an optimized treatment regimen of camrelizumab for Chinese patients with non-squamous non-small cell lung cancer. We will evaluate the efficacy, safety, and cost-effectivene...
Detailed Description
1. Evaluate the feasibility, safety, and preliminary efficacy of adding a β-adrenergic receptor blocker to standard anti-PD-1 immunotherapy (camrelizumab). Studies suggest that sympathetic nervous sys...
Eligibility Criteria
Inclusion
- (1)Histologically confirmed advanced (stage IIIB/IV) NSCLC; (2) Planned to receive first-line anti-PD-1/L1 monotherapy and deemed suitable for such treatment; (3) Older than 18 years of age; (4) ECOG (Eastern Oncology Collaboration group) score 0-1; (5) Ecg and liver and kidney function are normal; (6) No second primary tumor disease or serious complications.
Exclusion
- (1) Known hypersensitivity to camrelizumab or any of its excipients, or to any component of the planned β-blocker; (2) Clear contraindications to the use of a β-adrenergic receptor blocker; (3)Active infection requiring systemic therapy;(4)Any other concurrent severe illness or clinical condition that, in the investigator's judgment, would interfere with the completion or interpretation of the study protocol or increase patient risk.
Key Trial Info
Start Date :
January 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2025
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT05387512
Start Date
January 12 2022
End Date
November 30 2025
Last Update
January 6 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Pharmacy, Affiliated Hospital of Nantong University
Nantong, Jiangsu, China, 226000