Status:
UNKNOWN
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest
Lead Sponsor:
University of British Columbia
Conditions:
Hypoxia-Ischemia, Brain
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
The main outcome determinant following cardiac arrest is hypoxic ischemic brain injury. Management has involved increasing the delivery of oxygen to the brain. This logic assumes that oxygen transport...
Detailed Description
Purpose: To develop methods to differentiate between hypoxic ischemic brain injury patients exhibiting diffusion versus perfusion dependence. Secondarily, to investigate the underlying mechanisms resp...
Eligibility Criteria
Inclusion
- 1\) Greater than 19 years old post cardiac arrest with a Glasgow Coma Scale of 8 or less
- 2\) Invasive monitoring implemented within 72 hours of cardiac arrest
- 3\) Duration of cardiac arrest greater than 10 minutes.
Exclusion
- 1\) Coagulopathy (INR \> 1.5, PTT \> 40, Platelets \< 100x106 per microliter)
- 2\) Current or anticipated use of anticoagulant or antiplatelet medication
- 3\) Target temperature under 35oC; 4) history of severe TBI, intracranial hemorrhage or stroke.
Key Trial Info
Start Date :
October 27 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 27 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05390060
Start Date
October 27 2020
End Date
April 27 2025
Last Update
November 29 2023
Active Locations (1)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9