Status:
RECRUITING
MicroRNA Regulation of Chronic Inflammation During Aging
Lead Sponsor:
University of Utah
Conditions:
Chronic Inflammation
Eligibility:
All Genders
18+ years
Brief Summary
This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health...
Detailed Description
We will recruit healthy, non-obese (\<30kg/m2 BMI) younger (N=20; 18-35y) and older (N=20; \>65y) male and female participants (as determined by sample size calculation) in the Salt Lake City area. 1...
Eligibility Criteria
Inclusion
- Age between 18 - 35y; 65y and older
- BMI: \<30 kg/m2
- Ability to sign informed consent
- For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3
- Good general medical health, ambulatory and in independent living setting
Exclusion
- History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
- History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
- History of kidney disease or failure (CKD \> stage 4)
- History of vascular disease
- Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100
- Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
- Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
- Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
- Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
- History of stroke with motor disability
- A recent history (\<12 months) of GI bleed
- History of liver disease or AST/ALT 2 times above the normal limit
- History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
- Current smokers or current tobacco use
- Current pregnancy as determined by positive pregnancy test
- Any staff members who report directly to the principal investigators.
Key Trial Info
Start Date :
November 12 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05392582
Start Date
November 12 2024
End Date
January 1 2028
Last Update
December 5 2025
Active Locations (1)
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1
The University of Utah
Salt Lake City, Utah, United States, 84112