Status:
RECRUITING
Metagenomic Study in Parapneumonic Effusion
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Parapneumonic Effusion
Eligibility:
All Genders
18+ years
Brief Summary
Objective: To identify known and unknown bacterial pathogens in patients with pleural infections using a combination of conventional culture and next-generation sequencing approaches. Hypothesis to b...
Detailed Description
Parapneumonic effusion (PPE) is a common and serious clinical problem. Among patients suffering from community-acquired pneumonia, up to 57% of them would develop parapneumonic effusion (PPE), and 7.2...
Eligibility Criteria
Inclusion
- Study group (patients with parapneumonic effusion)
- Patients hospitalized for suspected pleural infection, irrespective of community-acquired or hospital-acquired in nature
- Pleural tapping will be performed for pleural fluid analysis
- Chinese ethnicity
- Aged 18 years old or above
Exclusion
- Use of antibiotics for more than 24 hours for the current episode of infection
- On long-term local or systemic antibiotics
- Tuberculous pleuritis
- Pregnant or lactating women
- Failed to obtain informed consent due to patient's refusal or cognitive impairment
- Control group (patients with effusions but not parapneumonic in nature)
- Inclusion Criteria:
- Pleural effusion is not related to any infection including pneumonia (e.g. malignancy, fluid overload)
- Pleural tapping will be performed for pleural fluid analysis
- Chinese ethnicity
- Aged 18 years old or above
Key Trial Info
Start Date :
June 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT05394220
Start Date
June 1 2023
End Date
May 31 2027
Last Update
June 29 2023
Active Locations (1)
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1
Chinese University of Hong Kong
Hong Kong, Hong Kong