Status:
RECRUITING
Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University
Conditions:
Intracranial Artery Stenosis
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients...
Detailed Description
sICASBLM aims to determine the effectiveness of conventional lipid management combined with PCSK9 inhibitors compared to conventional lipid management (atorvastatin 20-40mg or rosuvastatin 10-20mg or ...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
- low density lipoprotein cholesterol \> 70mg/dl (1.8mmol/L)
- Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
- Lipid-lowering indications of statins
- Signed an approved informed consents
Exclusion
- Contraindications to statins
- There are contraindications to MRI examination or cannot accept MRI examination
- Stenosis caused by vasculitis, arterial dissection and moyamoya disease
- Patients with active bleeding or obvious bleeding tendency
- Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating
- Uncontrolled severe diabetes and hypertension
- Other conditions inappropriate for inclusion judged by investigators
Key Trial Info
Start Date :
May 23 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05397405
Start Date
May 23 2022
End Date
May 1 2026
Last Update
November 15 2024
Active Locations (2)
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1
Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, China, 210006
2
Nanjing First Hospital
Nanjing, Jiangsu, China, 210006