Status:
RECRUITING
SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Head and Neck Squamous Cell Carcinoma
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Brief Summary
In this study, we aim to assess whether Patient Derived Organoids can be used to predict treatment sensitivity in HNSCC patients.
Detailed Description
This is a prospective observation study to generate patient-derived organoids from patients' samples to assess treatment response and to correlate with patients' treatment outcomes and to collect prel...
Eligibility Criteria
Inclusion
- Patients with head and neck squamous cell carcinoma (including oral cavity, oropharynx, paranasal sinuses, hypopharynx or larynx) undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers
- Age \> 18 years old
Exclusion
- Patients unable to give informed consent e.g. mental disability or vulnerable adults
Key Trial Info
Start Date :
June 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05400239
Start Date
June 1 2022
End Date
June 30 2025
Last Update
March 21 2024
Active Locations (1)
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1
Guys Hospital
London, United Kingdom, SE1 9RT