Status:
COMPLETED
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
Lead Sponsor:
Western Sydney Local Health District
Collaborating Sponsors:
Westmead Institute for Medical Research
Conditions:
Autosomal Dominant Polycystic Kidney
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is r...
Eligibility Criteria
Inclusion
- Diagnosis of Autosomal Dominant Polycystic Kidney Disease
- Age \> 18 years old
- Estimated Glomerular Filtration Rate (eGFR) \> 30 mL/min/1.73m2
- Treatment with at least one anti-hypertensive
Exclusion
- Inability to provide Informed Consent
- Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit
- Non-compliance with study procedures and/or daily BP measurements during the screening period
- Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs; cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolemia; pregnancy or post-partum and lactating)
- Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c \> 10%)
- Dislike of taste of beetroot juice
- Allergy to beetroot
- Enrolled in other clinical trials
Key Trial Info
Start Date :
May 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 24 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05401409
Start Date
May 5 2022
End Date
March 24 2023
Last Update
June 8 2025
Active Locations (2)
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1
Westmead Hospital
Sydney, New South Wales, Australia, 2145
2
Westmead Institute for Medical Research
Westmead, New South Wales, Australia, 2145