Status:
RECRUITING
Exploring the Recovery Function of Sleep in Neurodegeneration
Lead Sponsor:
University of Zurich
Conditions:
Neurodegenerative Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard...
Detailed Description
First, the investigators want to assess the relationship between sleep parameters (e.g. sleep intensity) and behavioral/cognitive performance and subjective measures (e.g. sleep quality, mood, and sle...
Eligibility Criteria
Inclusion
- Good general health or confirmed diagnosis of neurodegenerative disease associated with abnormal protein aggregation along international criteria
- Age above 18 years
- In ambulant setting: ability to apply the ambulant EEG device for the duration of the study, either alone or with help of co-habitant if MoCA \< 20
Exclusion
- Failure to give informed consent
- Inability to follow the procedures of the study, e.g. due to language problems or cognitive deficits
- Known or suspected non-compliance, drug- or medication abuse
- Inability to hear the tones to be applied during sleep in auditory stimulation experiments
- Skin disorders/problems/allergies in face/ear area that could worsen with electrode application
- Regular intake of drugs that may alter the relationship between sleep and outcome variables under investigation (opioids, benzodiazepines and z-drugs (nonbenzodiazepines)).
- Clinically significant concomitant disease states
- Too high (disease) burden for patients
- Additional non-medical exclusion criteria may be defined for certain cognitive tasks (e.g. no glasses during experiments involving eye tracking)
Key Trial Info
Start Date :
March 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05402488
Start Date
March 14 2022
End Date
June 1 2026
Last Update
June 2 2022
Active Locations (1)
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1
University Hospital Zurich, Neurology department
Zurich, Canton of Zurich, Switzerland, 8091