Status:
UNKNOWN
AOA Versus Non-AOA in Low Prognosis Patients by the POSEIDON Criteria
Lead Sponsor:
Mỹ Đức Hospital
Conditions:
in Vitro Fertilization
Eligibility:
FEMALE
35-45 years
Phase:
NA
Brief Summary
Poor ovarian response (POR) remains one of the significant challenges of Assisted Reproductive Technology (ART). Facing difficulties related to clinical practice, optimizing the embryo culture process...
Detailed Description
Poor ovarian response (POR) remains one of the significant challenges of Assisted Reproductive Technology (ART). Patients with POR yield a low number of oocytes, leading to a low number of useable emb...
Eligibility Criteria
Inclusion
- Was diagnosed as low prognosis patients by the POSEIDON criteria in group 4: maternal age ≥ 35 years old, AMH \< 1,2 ng/ml and AFC \< 5
- Cycles ≤ 3
- Oocytes could be collected with OPU procedure
- Ovarian stimulation with GnRH antagonist protocol
- Agree to participate in the randomization
Exclusion
- Uterine abnormalities such as unicornuate, bicornuate uterus, didelphys and adenomyosis
- Recent history of any current untreated endocrine abnormality
- Gonadotropin resistance syndrome
- Contraindications of gonadotropins
- Absolute asthernozoospermia
- Cryptozoospermia
- Surgical sperm retrieval
- Previous low fertilization (\< 30%)
- Globozoospermia
- Cycles using donor oocytes
- Preimplantation Genetic Testing (PGT) cycles
Key Trial Info
Start Date :
August 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
528 Patients enrolled
Trial Details
Trial ID
NCT05402605
Start Date
August 29 2022
End Date
June 30 2024
Last Update
August 30 2022
Active Locations (1)
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1
IVFMD, My Duc Hospital
Ho Chi Minh City, Vietnam