Status:
TERMINATED
Perioperative Individualized Optimization of Mean Arterial Pressure in Cardiac Surgery
Lead Sponsor:
University Hospital, Caen
Conditions:
Mean Arterial Pressure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Neurologic and renal complications frequently occur after cardiac surgery. Acute renal failure following cardiac surgery increase the risk of chronic kidney disease, while postoperative neurological c...
Detailed Description
Neurologic and renal complications frequently occur after cardiac surgery. Acute renal failure following cardiac surgery increase the risk of chronic kidney disease, while postoperative neurological c...
Eligibility Criteria
Inclusion
- Age \> 18 yr
- Patient scheduled for cardiac surgery with cardiopulmonary bypass (aortic valve repair or replacement and/or aortic surgery with normothermia and/or coronary artery bypass)
- Patient able to understand and voluntarily sign an informed consent form
- Patient able to adhere to the study visit schedule and other protocol requirements
- Patient affiliated with an appropriate social security system.
- French speaking patient
Exclusion
- Glomerular filtration rate \< 30 ml/min/1.73m2
- Neurologic disorder (motor and/or sensory deficit, cognitive disorder)
- Another type of surgery (emergency surgery, mitral or tricuspid repair or replacement, congenital surgery)
- Left ventricular ejection fraction \< 30% or acute heart failure in the month before surgery
- Pulmonary artery pressure \> 60 mmHg
- Endocarditis
- Surgery with hypothermia (\< 34°C)
- Hepatic cirrhosis (Score Child-Pugh ≥ 7)
- Alcohol use disorder (Score AUDIT C ≥ 5)
- Refusal to consent or adults with protective measures (curatorship or tutorship or safeguarding justice or juridical protection)
- Pregnancy or breast-feeding
Key Trial Info
Start Date :
January 12 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 17 2025
Estimated Enrollment :
172 Patients enrolled
Trial Details
Trial ID
NCT05403697
Start Date
January 12 2023
End Date
July 17 2025
Last Update
July 25 2025
Active Locations (1)
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1
CHU CAEN
Caen, France