Status:
RECRUITING
Botulinum Toxin Therapy in Hidradenitis Suppurativa
Lead Sponsor:
University of Massachusetts, Worcester
Collaborating Sponsors:
Hidradenitis Suppurativa Foundation
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Hidradenitis Suppurativa
Hyperhidrosis
Eligibility:
All Genders
18-75 years
Brief Summary
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the ...
Detailed Description
Botulinum toxin prevents vesicle fusion at nerve terminals thereby inhibiting neuropeptide release. The investigators will collect punch biopsies of lesional skin from HS patients before, and 1-2 mont...
Eligibility Criteria
Inclusion
- Inclusion:
- Adults between ages 18 and 75 years with established diagnosis of hidradenitis suppurativa (HS)
- HS skin lesions of duration at least 1 year, HS skin lesions in at least two different body areas
- Exclusion:
- Age \< 18 years or \> 75 years
- pregnant or breastfeeding
- neuromuscular disorder (ex. ALS, myasthenia gravis, Lambert-Eaton syndrome, myopathy)
- medical co-morbidity that is a relative contraindication to skin biopsy procedure (ex. end stage congestive heart failure or coagulopathy)
- active bacterial, fungal, or viral infection in the treatment area
- known hypersensitivity to botulinum toxin A preparations or any of their components (human albumin, saline, lactose, sodium succinate)
- prisoners
- adults unable to consent for themselves.
Exclusion
Key Trial Info
Start Date :
June 7 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05403710
Start Date
June 7 2022
End Date
April 30 2028
Last Update
September 15 2025
Active Locations (1)
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1
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States, 01605