Status:
RECRUITING
CAncer TReatment INformed by the Molecular Tumor Board At Dartmouth
Lead Sponsor:
Dartmouth-Hitchcock Medical Center
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a single-arm Phase II study to measure the impact of Molecular Tumor Board treatment recommendations on treatment decision-making in clinical practice at the Dartmouth Cancer Center. Following...
Eligibility Criteria
Inclusion
- Subject must provide verbal informed consent for study participation prior to MTB case evaluation.
- Tumor genetic profiling performed as standard of care must include ≥100 genes.
- Tumor must contain at least one of the following genetic alterations: (A) an alteration known to be potentially associated with sensitization to a clinically available treatment. (the list of genetic alterations evolves as new information emerges and new drugs are developed); (B) an alteration suspected to be germline.
- Subject must have ECOG Performance Status of 0 to 2.
- Subject must have measurable or evaluable disease.
- Subjects who have previously enrolled in this study can be enrolled a second time if they undergo genetic profiling of a tumor that was biopsied/sampled AFTER progression on an intervening line of treatment started after the time of first enrollment. Re-enrollment of such subjects must be noted in REDCap to facilitate longitudinal analysis.
- Age ≥18 years.
Exclusion
- Subjects with a tumor harboring a genetic alteration for which an FDA-approved drug is indicated that the patient has not yet received (example for exclusion: a melanoma with a BRAF-V600E mutation in a subject who has not yet been treated with a BRAF inhibitor).
- Pregnant women.
Key Trial Info
Start Date :
March 19 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2029
Estimated Enrollment :
192 Patients enrolled
Trial Details
Trial ID
NCT05405413
Start Date
March 19 2024
End Date
December 1 2029
Last Update
October 20 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756