Status:
COMPLETED
Remote Ischemic Conditioning With Novel Optical Sensor Feedback Device in Acute Ischemic Stroke
Lead Sponsor:
University of Alberta
Conditions:
Stroke, Acute Ischemic
Small Vessel Cerebrovascular Disease
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Stroke is a leading cause of physical and cognitive disabilities. The most common type of stroke is ischemic (lack of blood flow to the brain due to clot blocking a blood vessel). Many people with str...
Detailed Description
1. Hypothesis In patients with ischemic stroke and small vessel disease, Remote Ischemic Conditioning (RIC) delivered by novel device with optical feedback sensor will be safe and feasible. 2. Rationa...
Eligibility Criteria
Inclusion
- Adult patients with ischemic stroke (anterior and posterior circulation involvement) with or without neurological deficit within 48h of symptom onset
- CT head or MRI Brain evidence of infarct
- CT head or MRI Brain evidence of moderate or severe small vessel disease. We will assess atrophy, leukoaraiosis and old vascular lesions.
- Premorbid functional disability assessed by mRS \<2
- National institute of Health Stroke scale \<15 at the time of enrollment
Exclusion
- Patient is part of other clinical trial delivering intervention
- Injury to the upper arm or any other musculoskeletal disability/pain precluding from tolerating RIC therapy
- Treatment of ongoing malignancy with expected survival \< 6 months
- Presence of hypertensive urgency and emergency
- Presence of hemodynamic instability
- Presence of ongoing systemic infection with antibiotic therapy
- Pregnant and lactating women
- History of dermatological conditions affecting application of tissue perfusion sensor and remote ischemic conditioning pressure cuff
Key Trial Info
Start Date :
July 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2024
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT05408130
Start Date
July 7 2022
End Date
August 1 2024
Last Update
August 28 2024
Active Locations (1)
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1
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7