Status:
COMPLETED
Vitamin D and Microvascular Function in Postmenopausal Women
Lead Sponsor:
Rio de Janeiro State University
Collaborating Sponsors:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Conditions:
Menopause Related Conditions
Vitamin D Deficiency
Eligibility:
FEMALE
45-60 years
Brief Summary
Many observational studies have demonstrated links between serum levels of 25-hydroxyvitamin D \[25(OH)D\] and cardiovascular risk (CVR) factors. Microvascular dysfunction relates not only to CVR but ...
Eligibility Criteria
Inclusion
- Women between 45-60 years with clinical/laboratory criteria of menopause and duration of hypoestrogenism \< 10 years. Menopause was spontaneous (at least one year of amenorrhea) or surgical (after bilateral oophorectomy). In hysterectomized women, ovarian failure was estimated by the history of vasomotor symptoms and serum levels of follicle-stimulating hormone (FSH) \> 35 mU/mL and estradiol levels \<20 pg/mL.
Exclusion
- Current smokers, body mass index (BMI) \>35 kg/m², systolic BP \>160 mmHg and or diastolic BP \> 100 mmHg, total cholesterol \>280 mg/dL, presence of T2D, renal dysfunction and or liver disease, clinical manifestations of coronary heart disease, and previous history of revascularization or cardiovascular event.
Key Trial Info
Start Date :
July 4 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 17 2021
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT05408273
Start Date
July 4 2019
End Date
December 17 2021
Last Update
June 7 2022
Active Locations (1)
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1
State University of Rio de Janeiro
Rio de Janeiro, Brazil, 20559900