Status:
COMPLETED
Acute Effects of Added Sugar Intake on Cerebrovascular Function and Brain Integrity
Lead Sponsor:
University of Delaware
Conditions:
Healthy Diet
Healthy Aging
Eligibility:
All Genders
30-64 years
Phase:
NA
Brief Summary
This study will focus on acute effects of added sugars on brain health in a specific age group (30-64 years old). We will provide participants two meals (one meal containing 16 g of added sugars and t...
Detailed Description
Cardiometabolic risk factors are strongly influenced by lifestyle-related environmental factors including the consumption of an unhealthy Western diet (WD). Added sugars (i.e., caloric sweeteners adde...
Eligibility Criteria
Inclusion
- Ability to provide informed consent;
- Men and women within the ages of 30-64 years;
- Habitual added sugar intake of \<150 kcal/day for men and \<100kcal/day for women;
- No allergies/intolerance to ingredients in the study meal (e.g., nuts, gluten)
Exclusion
- Blood chemistries indicative of abnormal liver enzymes and renal function;
- Abnormal blood chemistry marker that is +/-2.5x the upper or lower limit;
- Chronic clinical diseases (e.g., coronary artery, peripheral artery, or cerebrovascular diseases, diabetes (type 1 and type 2), stages 5-6 chronic kidney disease, chronic obstructive pulmonary disease);
- Major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years);
- Neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct);
- Current medication use likely to affect central nervous system functions (e.g. long active benzodiazepines) and lipid-lowering medications (e.g., statins)
- Conditions which would contra-indicate MRI: implant of pacemakers or pacemaker wires; artificial heart valve; brain aneurysm surgery; middle ear implant; non-removable hearing aid or jewelry; braces; cataract surgery or lens implant; implanted mechanical or electrical device; foreign metallic objects in the body such as bullets, BBs, shrapnel, or metalwork fragments, claustrophobia;
- Current smoking;
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
June 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 17 2023
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT05408338
Start Date
June 14 2022
End Date
April 17 2023
Last Update
May 10 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Delaware
Newark, Delaware, United States, 19713