Status:
COMPLETED
Astaxanthin, Exercise Inflammation, Skin Health
Lead Sponsor:
Appalachian State University
Collaborating Sponsors:
LycoRed Ltd.
Conditions:
Inflammatory Response
Metabolic Disturbance
Eligibility:
All Genders
18-57 years
Phase:
NA
Brief Summary
Vigorous exercise can stress the body. Consuming special types of diet supplements may help the body recover better from exercise. This includes a bright red supplement called astaxanthin that is foun...
Detailed Description
RESEARCH PROCEDURES The research procedures will be conducted at the Human Performance Laboratory (Room 1201, Plants for Human Health Institute Building, 600 Laureate Way), operated by Appalachian Sta...
Eligibility Criteria
Inclusion
- Male or female, ages 18-57 years.
- Non-smoker.
- Capable of running 2.25 h on laboratory treadmills at 70% VO2max (close to marathon race pace).
- Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation and immune function (especially Advil, Motrin, aspirin, and similar anti-inflammatory drugs) for the duration of the 10-week study. (Review supplement and medication use with the Research Manager during orientation).
- Agree to taper exercise training prior to each of the two lab running sessions (as if preparing for a race).
- Willing to avoid astaxanthin supplements (other than what is provided) and natural sources of astaxanthin including algae, yeast, salmon, trout, krill, shrimp and crayfish during the 10-week study.
- Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
- Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.
Exclusion
- Inability to comply with study requirements.
- Body weight below 110 pounds.
- Pregnant or breastfeeding.
- Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
- Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
- History of allergic reactions to astaxanthin.
- Using drugs with 5-alpha-reductase inhibitor (Proscar, Propecia, Avodart, Jalyn).
Key Trial Info
Start Date :
January 19 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2022
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT05409092
Start Date
January 19 2022
End Date
December 30 2022
Last Update
June 9 2023
Active Locations (1)
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1
Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081