Status:
COMPLETED
Mangoes and Exercise Inflammation
Lead Sponsor:
Appalachian State University
Conditions:
Inflammatory Response
Muscular Injury
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Vigorous exercise bouts result in significant inflammation and muscle soreness. Our research group has published several papers showing that ingestion of various types of fruits enhances inflammation ...
Detailed Description
Subjects will come to the lab for orientation/baseline testing, pre-and post-supplementation (2 weeks mango ingestion compared to water alone) blood and urine sample collections with 3-d food records,...
Eligibility Criteria
Inclusion
- Male or female cyclist, ages 18-60 years, and capable of cycling 2.25 h in the lab on trainers at 70% VO2max (close to race pace).
- Non-smoker, and generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis. Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
- Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation (especially NSAIDs) for the duration of the 6-week study and at least a 2-week period prior to the study.
- Agree to taper their exercise routine prior to each of the two lab cycling sessions.
- Agree to avoid ingestion of mangoes (fresh or within other products) during the study (other than provided).
Exclusion
- Inability to comply with study requirements, history of allergic reactions to mangoes.
- Females: body weight below 110 pounds; pregnant or breastfeeding.
- Any other concurrent condition which, in the opinion of the principle investigator (PI), would preclude participation in this study or interfere with compliance.
- Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
Key Trial Info
Start Date :
August 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2023
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT05409105
Start Date
August 15 2022
End Date
January 30 2023
Last Update
June 12 2023
Active Locations (1)
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1
Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081