Status:
COMPLETED
Fatigability in Persons With Multiple Sclerosis: Inputs From Cognition, Walking and Coordination
Lead Sponsor:
Hasselt University
Collaborating Sponsors:
Revalidatie & MS Centrum Overpelt
National MS Center Melsbroek
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
Walking impairments occur in 93% of persons with MS (pwMS) within 10 years of diagnosis. Besides the impact of muscle weakness or hypertonia, one is increasingly aware about the symptom of fatigabilit...
Detailed Description
The study will have two parts (A and B). Part A includes 60 persons with Multiple Sclerosis (pwMS) and 30 healthy controls. The study consists of 2 test sessions, separated by 5-7 days of interval. Th...
Eligibility Criteria
Inclusion
- Persons with MS presenting walking-related fatigability (Distance walk index ≤-10);
- age between 30 and 70 years old;
- a diagnosis of MS (2017 revisions of the McDonalds criteria) with Expanded Disability Status Scale (EDSS) 4 up to 6.5.
- no relapses \>1 month preceding the start of the study
- ability to walk for 6 minutes without rest.
Exclusion
- Cognitive impairment hindering understanding of study instructions,
- pregnancy
- musculoskeletal disorders in the lower limbs not related to MS.
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT05412043
Start Date
September 1 2021
End Date
May 30 2024
Last Update
July 22 2024
Active Locations (2)
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1
Noorderhart Revalidatie & MS centrum
Overpelt, Belgium, 3900
2
National MS Center Melsbroek
Overpelt, Belgium