Status:
RECRUITING
Improving Quality of Life and Daily Life Activities With Bioarginine in Patients With COPD
Lead Sponsor:
University of Milan
Conditions:
COPD
Dyspnea
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Different studies have suggested that COPD is associated with elevated alveolar NO and increased expression of NOS2 in alveolar walls, small airway epithelium and vascular smooth muscle. Furthermore, ...
Eligibility Criteria
Inclusion
- \> 40 years old
- Smoke history \>10 pack years (PYs)
- Forced expiratory volume (FEV1 70-40% predicted)
- COPD Assessment Test score \>= 10
- Stable Inhaled therapy in the three months prior to study enrollment
Exclusion
- Exacerbations in the three months prior to study enrolment
- Dementia and inability to perform study test bundles
- Interstitial lung disease
- History of asthma
- Patients unable to perform a 6MWT or necessitating a walker to ambulate
- Long term oxygen therapy (excluding patients on nocturnal O2 therapy)
- Patients enrolled In pulmonary rehabilitation programs during the study or that have completed a pulmonary rehabilitation program in the 6 months before study enrollment
Key Trial Info
Start Date :
January 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2024
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT05412160
Start Date
January 18 2023
End Date
January 31 2024
Last Update
January 9 2024
Active Locations (1)
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1
L. Sacco Hospital
Milan, Italy, 20157