Status:
UNKNOWN
The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients With Retinitis Pigmentosa
Lead Sponsor:
TC Erciyes University
Conditions:
Retinitis Pigmentosa
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
PHASE3
Brief Summary
This clinical trial aims to study the efficacy of umbilical cord-derived mesenchymal stem cells and their exosomes in the treatment of retinitis pigmentosa. The participants will be randomized into 3 ...
Detailed Description
Retinitis pigmentosa (RP) is one of the leading causes of vision loss and irreversible blindness. It is stated that 1.4 million people are affected in the world and its prevalence is 1:4000. Stem cell...
Eligibility Criteria
Inclusion
- 18 years and over,
- Diagnosis of retinitis pigmentosa: by clinical history, fundus examination, visual field (GA), electroretinogram (ERG), and genetic analysis
- Visual field loss
- The best corrected visual acuity of 0.05 on the Snellen chart
- The MD (mean deviation) value in the visual field is between 33.0 and -5.0 dB
- Intraocular pressure value below 22 mmHg
Exclusion
- Presence of cataracts or other media opacities that may affect imaging and tests
- Diagnosis of glaucoma
- History of ocular surgery or injection in the last 6 months
- Visual level too low for examinations (0.05 and below)
- Diagnosis of any systemic disease (such as diabetes, uncontrolled hypertension, neurological disease)
- Smoking and substance abuse
Key Trial Info
Start Date :
August 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2023
Estimated Enrollment :
135 Patients enrolled
Trial Details
Trial ID
NCT05413148
Start Date
August 5 2022
End Date
December 15 2023
Last Update
September 7 2022
Active Locations (1)
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1
Erciyes University, Faculty of Medicine
Kayseri, Turkey (Türkiye), 38039