Status:
UNKNOWN
Effect of Airway Pressure Release Ventilation on Right Ventricular Function Assessed by Transthoracic Echocardiography
Lead Sponsor:
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions:
Ventilation Therapy; Complications
Right Ventricular Function
Eligibility:
All Genders
18-80 years
Brief Summary
Effects of APRV on right ventricular function in patients with acute respiratory distress syndrome by transthoracic echocardiography
Detailed Description
Effects of APRV on right ventricular function in patients with acute respiratory distress syndrome(ARDS) by transthoracic echocardiography，which includes TAPSE, S' by TDI, RV FAC, tricuspid regurgitat...
Eligibility Criteria
Inclusion
- Patients who meet the 2012 Berlin ARDS diagnostic criteria and undergo invasive mechanical ventilation
- PEEP≥5cmH2O, oxygenation index≤200mmHg
- Endotracheal intubation and mechanical ventilation time \<48h
- Age ≥18 years old and ≤80 years old
Exclusion
- Aged less than 18 years old or older than 80 years old
- Obese patients with BMI≥35kg/m2;
- Pregnant and lactating women
- The expected time of invasive mechanical ventilation is expected to be less than 48h
- Neuromuscular disease known to require prolonged mechanical ventilation
- Severe chronic obstructive pulmonary disease
- Intracranial hypertension
- Bullae or pneumothorax, subcutaneous emphysema, mediastinal emphysema
- extracorporeal membrane oxygenation(ECMO) has been performed when entering the ICU
- Refractory shock
- Severe cardiac dysfunction (New York Heart Association class III or IV, acute coronary syndrome or persistent ventricular tachyarrhythmia), right heart enlargement due to chronic cardiopulmonary disease, cardiogenic shock or heart enlargement postoperative;
- Failure to sign informed consent
Key Trial Info
Start Date :
April 3 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 15 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05414110
Start Date
April 3 2022
End Date
February 15 2024
Last Update
June 10 2022
Active Locations (1)
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1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430000