Status:
RECRUITING
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
University of Oxford
Conditions:
Muscle Atrophy
Age-Related Sarcopenia
Eligibility:
MALE
50-90 years
Phase:
NA
Brief Summary
As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent. However, not everyone can perform this exercise and the ...
Detailed Description
Skeletal muscle is known for its role in locomotion however, muscles are also important for maintaining whole-body metabolic health. Skeletal muscles represent a vast protein store, the amino acids fr...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study
- Participant is physically able to complete the resistance exercise training programme
Exclusion
- • A BMI \<18 or \>35 kg/m2
- Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent stroke
- Any metabolic disease
- Clotting dysfunction
- A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy)
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)
- Contraindications to MRI scanning including claustrophobia, pacemaker, metal implants etc. which will be assessed through an MRI safety screening questionnaire.
- Contraindications to the use of Rapamycin e.g. those due scheduled vaccinations (as rapamycin can reduce the efficacy of vaccines).
Key Trial Info
Start Date :
August 6 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT05414292
Start Date
August 6 2021
End Date
May 1 2027
Last Update
April 10 2025
Active Locations (1)
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1
University of Nottingham School of Medicine
Derby, United Kingdom, DE22 3DT