Status:

UNKNOWN

Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination

Lead Sponsor:

Beijing Tiantan Hospital

Collaborating Sponsors:

Tianjin Medical University General Hospital

Conditions:

NMO Spectrum Disorder

NMDA-R Encephalitis

Eligibility:

All Genders

18+ years

Brief Summary

Determination of autoantibodies against fragments derived from neurons, glia, and myelin sheath is instrumental in aiding diagnosis, differential diagnosis, as well as determining disease status of ne...

Detailed Description

Participants: The sera of patients with CNS demyelinating autoimmune diseases (NMOSD, MOGAD, AE). Primary aim: 1) Compare the specificity, sensitivity, and clinical correlation between CBA and CBA-TS...

Eligibility Criteria

Inclusion

  • The patients with suspected NMOSD, MOGAD and AE will be recruited.
  • Male and female patients, ≥ 18 years old.

Exclusion

  • Abnormal sera, such as hemolysis or lipemia, which will affect the final interpretation of CBA and CBA-TSA;
  • The samples with incomplete clinical data that would affect the disease characterization.

Key Trial Info

Start Date :

June 30 2022

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

June 30 2024

Estimated Enrollment :

2500 Patients enrolled

Trial Details

Trial ID

NCT05414890

Start Date

June 30 2022

End Date

June 30 2024

Last Update

June 10 2022

Active Locations (1)

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Beijing Tiantan Hospital

Beijing, Beijing Municipality, China, 100010