Status:
RECRUITING
Assessment of the Ocular Microbiome in Health and Disease
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Microbial Colonization
Eye Diseases
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the he...
Detailed Description
The microbiome is defined as a community of microbial organisms that reside in a specific host niche. There is a growing body of literature on the association between gut microbiome and disease entiti...
Eligibility Criteria
Inclusion
- We will include subjects who meet all of the following criteria:
- 18 years of age or older
- Provide informed consent
- Cohort A - normal eyes with no ocular disease
- Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
- Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
- Cohort D - Dry AMD (age related macular degeneration)
- Cohort E - Wet AMD
- Cohort F - diabetic retinopathy
Exclusion
- We will exclude subjects who meet all of the following criteria:
- Prior ocular disease either of the anterior or posterior segment
- Any medical comorbidities except well controlled DH and HTN
- Unable to follow up with study procedures as described
Key Trial Info
Start Date :
September 7 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT05414994
Start Date
September 7 2023
End Date
December 30 2027
Last Update
October 6 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232