Status:
COMPLETED
Denosumab Effect on Bone Quality and Function After Lumbar Fusion Surgery
Lead Sponsor:
Shenzhen People's Hospital
Conditions:
Osteopenia
Spine Fusion
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
Degenerative lumbar spinal diseases have become a common health problem and the most frequent indication for spinal surgery in elderly individuals. It mainly contain lumbar spinal stenosis and spondyl...
Detailed Description
However, It was still unknown for denosumab effect on osteopenia patients after lumbar fusion. Bone mineral density(BMD), bone turnover marker, lumbar functional status Roland-Morris Disability Functi...
Eligibility Criteria
Inclusion
- Participants aged 40 to 85 years
- who diagnosed with lumbar spinal stenosis or lumbar spondylolisthesis
- osteopenia with BMD T score between -1.0 and -2.5 via dual-energy X-ray
- low back pain or leg numbness or weakness
- MRI demonstrated signs of nerve compression
Exclusion
- cauda equina syndrome
- progressive neurologic deficit
- history of cancer
- scoliosis greater than 15°
- back open surgery history
- have contraindications for surgery
- who had anti-osteoporosis medication within 6 weeks
Key Trial Info
Start Date :
January 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 10 2023
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT05415657
Start Date
January 12 2020
End Date
January 10 2023
Last Update
January 18 2023
Active Locations (1)
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1
ShenzhenPH
Shenzhen, Guangdong, China, 518000