Status:
UNKNOWN
Effect of Esketamine on Abdominal Pain During TACE-HAIC in Patients With Hepatocellular Carcinoma
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Hepatocellular Carcinoma
Transarterial Chemoembolization
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Previous studies have confirmed that limb pain caused by oxaliplatin chemotherapy is related to spinal cord central sensitization - induced hyperalgesia through oxaliplatin activating spinal cord NMDA...
Eligibility Criteria
Inclusion
- Participate in this study and sign informed consent
- Voluntarily receive postoperative intravenous controlled analgesia
- Patients receiving TACE-HAIC treatment
- HCC (hepatocellular carcinoma)patients with primary liver cancer BCLC(Barcelona Clinic Liver Cancer) stage B and C, liver function A
- Age 18 to 80
Exclusion
- Patients who were unable to cooperate or refused to participate in the trial
- Pregnant women
- Patients with sensory abnormalities such as diabetes neuropathy
- Patients with or having a history of serious mental disorders
- Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure more than 180/100mg)
- Patients with unstable angina pectoris or myocardial infarction within 6 months or congestive heart failure
- Patients with intracranial hypertension or glaucoma
- Patients with hyperthyroidism without treatment or insufficient treatment
- Patients with severe respiratory dysfunction
- Allergy or existing contraindication to chemotherapeutic drugs, opioids or ketamine drugs
- Can not follow with the study procedure
Key Trial Info
Start Date :
June 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2023
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT05416073
Start Date
June 22 2022
End Date
April 30 2023
Last Update
February 24 2023
Active Locations (1)
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1
The Second Affiliated Hospital, Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400010