Status:
RECRUITING
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Lung Cancer
Lung Cancer Metastatic
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.
Eligibility Criteria
Inclusion
- Histologic diagnosis of small cell lung cancer
- Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
- Age 18 and above
- Performance status KPS 60-100/ECOG 0-2
- Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
- The patient or legally authorized representative is able to provide informed consent
Exclusion
- Unable to undergo contrast-enhanced MRI brain or spine
- Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
- Pregnant or lactating women
- Prior brain-directed radiotherapy
- Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment
Key Trial Info
Start Date :
June 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 10 2026
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT05419076
Start Date
June 10 2022
End Date
June 10 2026
Last Update
November 13 2025
Active Locations (7)
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1
Memorial Sloan Kettering at Basking Ridge
Basking Ridge, New Jersey, United States, 07920
2
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
3
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
4
Memorial Sloan Kettering Suffolk - Commack
Commack, New York, United States, 11725