Status:
COMPLETED
Impact of Aerobika OPEP in Improving Small Airway Parameters in COPD
Lead Sponsor:
National University of Malaysia
Conditions:
COPD
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Research Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease that makes breathing difficult with mucus build-up in the inflamed airway and lungs hyperinflatio...
Detailed Description
IOS is a simple, non-invasive method requiring only passive patient cooperation without special manoeuvre for evaluation of lung function through the measurement of both airway resistance and airway r...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age 40 years or older
- COPD diagnosed according to the GOLD guidelines: GOLD 2 - GOLD 4
- Stable COPD patients with mucus hyperproduction: coughed and brought up sputum "several days a week" (\>2 days a week) or "almost every day" in the month prior to the study
- Patients who can perform IOS
- Patients who can perform spirometry
- Patients who can perform 6MWT
- Exclusion Criteria:
- COPD diagnosed according to the GOLD guidelines: GOLD 1
- Diagnosis of other chronic lung diseases: Asthma, Asthma-COPD Overlap, Interstitial Lung Disease, Bronchiectasis, Lung Cancer
- Patients with contraindication for spirometry: recent cardiac complications, major surgery, severe advanced respiratory disease, or those with cognitively or neurologically impairment
- Patients not recommended for OPEP: neuromuscular weakness, recent facial, oral or skull surgery or trauma, recent oesophageal surgery, active haemoptysis, acute sinusitis, untreated pneumothorax, known or suspected tympanic membrane rupture or other middle ear pathology, overt right-sided heart failure
- Patients with contraindication for 6 minute walking test
- Patient unable or unwilling to give informed consent
- Change of inhaler during study period
Exclusion
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT05420740
Start Date
July 1 2022
End Date
June 1 2023
Last Update
November 14 2023
Active Locations (1)
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1
National University of Malaysia
Kuala Lumpur, Kuala Lumpur, Malaysia, 56000