Status:
COMPLETED
Olfactory Training in COVID-19 Associated Loss of Smell
Lead Sponsor:
Medical University Innsbruck
Conditions:
COVID-19
Hyposmia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Olfactory dysfunction (OD) like hyposmia or anosmia has been realized as a common symptom or even cardinal sign of the disease and can be persisting after recovering. There are two different hypothes...
Eligibility Criteria
Inclusion
- The subject is aged over 18 years;
- confirmed diagnosis of COVID-19 at least three months ago (history of positive PCR-testing required) or positive serum nucleocapsid antibody titer against SARS-CoV2;
- post-infectious COVID-19 related olfactory dysfunction persisting for at least three months with abnormal Sniffin' sticks test (\<13/16 items correct in the identification part);
- the patient is willing to undergo odor training over 12 weeks;
- written ICF is obtained.
Exclusion
- History of olfactory dysfunction prior to COVID-19 infection due to other conditions e.g. status post traumatic brain injury, Parkinson's disease, allergic rhinitis, etc.;
- Nasal pathology not related to COVID-19 in the systematic otorhinolaryngological examination including endoscopy.
- the participant is pregnant
Key Trial Info
Start Date :
August 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT05421221
Start Date
August 10 2022
End Date
December 31 2024
Last Update
April 23 2025
Active Locations (1)
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1
Medical University of Innsbruck
Innsbruck, Tyrol, Austria, 6020